Italian to English Medical Medical: Health Care Audiology

IT = È importante precisare, peraltro, che il valore di un buon metodo consiste nel misurare non soltanto la perdita uditiva, ma in particolare la disabilità uditiva, ovvero quanto l'abbassamento delle performance uditive insiste sulle condizioni psicofisiche generali e la qualità della vita del paziente.

EN = It is important to note, moreover, that the value of a good method lies in measuring not only hearing loss, but specifically hearing disability, and to what extent the reduction in hearing performance affects general psychophysical conditions and the patient’s quality of life.

I am not sure whether "insiste" here should be rendered by "affects", " is affected by", "is conditioned by", or something else... Dictionary entries, i.e. insist, persist, persevere, repeat, rest on, etc. are not helpful.
Any ideas would be most appreciated?
Thank you.